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Using two separate drugs to shed weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it one should err assisting caution and permit the FDA do its job and demand some investigation be done in order that the public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies are in business to make money and that they would say anything to keep people on their own medications. Researchers discovered that participants taking this drug for any year, lost excess weight within four weeks and have kept the weight off during the entire 56 weeks in the study. Contrave is a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which might be made up of many active ingredient, that might make them more potent and safer. Combo-pilling will be the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular is the fact that as of right now there are no long term prescription diet pills that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug could also raise blood pressure levels and heartbeat, and mustn't be used in those with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure level, and also by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. "This will be the first drug I'm mindful of that targets both appetite and reward centres inside brain," he explained.